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KMID : 0363320040250010016
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Journal of Korean Oriental Internal Medicine
2004 Volume.25 No. 1 p.16 ~ p.27
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Immunomodulatory activities of ethanolic extract of Drynariae Rhizoma
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Lee Ki-Uk
Jung Ji-Chun
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Abstract
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In the traditional Chinese medicine, Drynariae Rhizoma (DR) has been reported as a good enhancer for bone healing. DR, a plant widely used in the traditional medicinal systems of Korea, has been reported to possess antiviral, antibacterial and anti-inflammatory activities. Modulation of immune response to alleviate disease has been of interest for a long time. Plant extracts have been widely investigated for possible immunomodulatory properties. Thus, I have evaluated the anticellular and immunomodulatory properties of ethanolic extract of DR. DR extract inhibited proliferation of mitogen (phytohaemagglutinin; PHA) and antigen (purified protein derivative; PPD)-stimulated human peripheral blood mononuclear cells (PBMCs). In addition, DR inhibited growth of several cell lines of mouse and human origin. It also inhibited production of nitric oxide (NO), interleukin-2 (IL-2) and tumor necrosis factor-{alpha};(TNF-{alpha}). Intracytoplasmic interferon-{gamma};(IFN-{gamma}) and expression of cell surface markers, CD16 and HLA-DR, on human PBMC, were not affected on treatment with DR but CD25 expression was down regulated. This study demonstrates the antiproliferative and immunosuppressive potential of ethanolic extract of DR in vitro.
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KEYWORD
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Drynariae Rhizoma, cell surface markers, lymphocyte proliferation, PHA, nitric oxide, IL-2, TNF-{alpha}, intracellular IFN-{gamma}
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